Overexpression of Aromatase Associated With Loss of Heterozygosity of the<i>STK11</i>Gene Accounts for Prepubertal Gynecomastia in Boys with Peutz-Jeghers Syndrome

Abstract

Loss of heterozygosity of the STK11 gene leads to an increase in aromatase expression associated with an increase in CRTC nuclear localization, thereby providing a mechanism whereby PJS results in increased endogenous estrogens in affected males.