EFFECT OF A PHENYLBUTAZONE ANALOG (4-[PHENYLTHIOETHYL]-1,2-DIPHENYL 3,5-PYRAZOLIDINEDIONE) ON URATE CLEARANCE AND OTHER DISCRETE RENAL FUNCTIONS IN GOUTY SUBJECTS. EVALUATION AS URICOSURIC AGENT 1

Abstract

A number of phenylbutazone derivatives and metabolites are under study (1-4) in a joint effort to develop an analog possessing the marked anti-rheumatic properties but not the undesirable side effects of the parent compound. In the course of testing the anti-rheumatic effects in acute gouty arthritis of one of these compounds, G-25671, in which a phenylthioethyl group replaces the butyl side chain of phenylbutazone, marked uricosuric activity was noted (1, 2). The interesting properties of this substance suggested further study and a clinical trial in the management of gout. N (Xi} N C=O O= -CH2-CH2-CH2-CH3 H Phenylbutazone