Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, α-phellandrene, and essential oil from<i>Schinus terebinthifolius</i>fruits in a neuropathic pain model

Abstract

Together, the results of the present work show that essential oil of S. terebinthifolius and compounds present in this oil, including (R)-(+)-limonene and α-phellandrene, exhibit antihyperalgesic effects against mechanical hyperalgesia, and are antidepressive, while only α-phellandrene inhibited cold hyperalgesia in SNI rats.