Radiology · 1994 · 380 citations · 17 references
MedicineNeuroscienceNeurosurgeryDiagnostic ImagingMotor NeuroscienceNeuro-oncologyBrain ImagingFunctional NeuroimagingMagnetic Resonance ImagingMotor CortexSensory-motor IntegrationSomatosensory CortexCortical LocalizationCortical MappingDirect Cortical StimulationFunctional ImagingFunctional Magnetic Resonance ImagingMagnetic ResonanceSensory Cortex MappingTask-based Activation Mapping
Both patients had intractable simple partial motor seizures caused by tumors located in or near the sensory motor cortex. The study aimed to describe a clinically useful application of functional MR imaging for presurgical mapping of the sensory motor cortex and to validate its results against established physiologic techniques. Functional MR mapping of the sensory motor cortex was performed in two women, followed by invasive cortical mapping—direct cortical stimulation and/or sensory‑evoked‑potential recording—to localize the affected area before tumor resection. In both patients, functional MR imaging demonstrated task activation of the sensory motor cortex, and its results matched those obtained with invasive mapping, indicating that presurgical mapping with functional MR imaging is a potentially useful clinical tool.
PURPOSE: To describe a clinically useful application of functional magnetic resonance (MR) imaging--presurgical mapping of the sensory motor cortex--and to validate the results with established physiologic techniques. MATERIALS AND METHODS: Functional MR mapping of the sensory motor cortex was performed in two women, aged 24 and 38 years. Both had intractable, simple partial motor seizures due to tumors located in or near the sensory motor cortex. They subsequently underwent invasive cortical mapping--direct cortical stimulation and/or sensory-evoked-potential recording--to localize the affected sensory motor area prior to tumor resection. RESULTS: In both patients, the functional MR study demonstrated task activation of the sensory motor cortex. In both cases, results of cortical functional mapping with invasive techniques matched those obtained with functional MR imaging. CONCLUSION: Presurgical mapping of the sensory motor cortex is a potentially useful clinical application of functional MR imaging.
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Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Satoshi Ogawa, T M Lee, A R Kay et al. · Proceedings of the National Academy of Sciences · 1990 · 6.5K citations · Full text
Medicine, Neuroscience, Radiology +17