Synthesis of (cis-6-methyltetrahydropyran-2-yl)acetic acid involving the use of an organoselenium-mediated cyclization reaction - Concepedia

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Synthesis of (cis-6-methyltetrahydropyran-2-yl)acetic acid involving the use of an organoselenium-mediated cyclization reaction

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1982

Year

Steven V. Ley, Barry Lygo, H. MOLINES, Judith A. Morton

Journal of the Chemical Society Chemical Communications

EngineeringHeterocyclicNovel Organoselenium-mediated CyclizationAlkenyl-substituted β-OxoestersOrganic ChemistryOrganoselenium-mediated Cyclization ReactionStereoselective SynthesisChemistrySynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringAcetic Acid

Abstract

A short stereospecific synthesis of (cis-6-methyltetrahydropyran-2-yl)acetic acid (1) has been achieved from readily available starting materials using a novel organoselenium-mediated cyclization of alkenyl-substituted β-oxoesters.