Novel germlineBRCA1 mutations detected in women in Singapore who developed breast carcinoma before the age of 36 years

Abstract

The spectrum of germline BRCA1 mutations among the patients in this study was distinct from that in Caucasian populations although a similar prevalence was observed. Larger studies are necessary to clarify the significance of the mutation 2846insA in the Malay community and the penetrance of specific mutations in the Singapore population.