Outbreak of Clindamycin-Associated Colitis

Abstract

Letters1 December 1975Outbreak of Clindamycin-Associated ColitisSHERWIN A. KABINS, M.D., F.A.C.P., THOMAS J. SPIRA, M.D.SHERWIN A. KABINS, M.D., F.A.C.P.Search for more papers by this author, THOMAS J. SPIRA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-830 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClindamycin-associated colitis has been reported by the manufacturer to occur once in 50 000 to 100 000 treatment courses (1). Tedesco, Barton, and Alpers (2) reported a 10% incidence in a prospective study in St. Louis. Ramirez-Ronda (3) in a retrospective analysis reported an incidence of 1 in 5000 to 10 000 in the Dallas area. In addition, a feature that defies explanation has been a marked geographic variability in the distribution of cases (personal communication from G. L. Royer, Jr., M.D., The Upjohn Company, Kalamazoo, Michigan). We report an outbreak of clindamycin-associated colitis affecting 9 patients during a 2-month...References1. : Letter to Physicians. 16 August 1974 Google Scholar2. TEDESCOBARTONALPERS FRD: Clindamycin-associated colitis: a prospective study. Ann Intern Med 81:429-433, 1974 LinkGoogle Scholar3. RAMIREZ-RONDA C: Incidence of clindamycin-associated colitis. Ann Intern Med 81:860, 1974 LinkGoogle Scholar4. BURLUGEMILLIGAN EF: Pseudomembranous colitis: association with antibiotics and therapy with cholestyramine. JAMA 231:1157-1158, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SHERWIN A. KABINS, M.D., F.A.C.P.; THOMAS J. 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