Insulin Resistance Is Independently Associated with Liver Aminotransferases in Diabetic Patients Without Ultrasound Signs of Nonalcoholic Fatty Liver Disease

Abstract

In type 2 diabetes, in the absence of a detectable steatosis by ultrasonography, ALT and AST are associated with hyperinsulinemia and insulin resistance, independent of obesity. This finding possibly indicates that in diabetes a mild stage of steatosis is sufficient to mediate the association between insulin resistance and aminotransferases.