Effect of Elevated Intra-Abdominal Pressure and Hyperoxia on Portal Vein Blood Flow, Hepatocyte Proliferation and Apoptosis in a Rat Model - Concepedia

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Effect of Elevated Intra-Abdominal Pressure and Hyperoxia on Portal Vein Blood Flow, Hepatocyte Proliferation and Apoptosis in a Rat Model

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References

2008

Year

J. Mogilner, Haim Bitterman, Lili Hayari, Vera Brod, A. G. Coran, Ron Shaoul, M. Lurie, Samuel Eldar, Igor Sukhotnik

European Journal of Pediatric Surgery

Abstract

Despite a significant decrease in PV blood flow, persistent IAP for 2 hours results in few changes in liver histology, and stimulates hepatocyte proliferation and apoptosis in only a few animals, supporting the presence of a recovering mechanism. Treatment with hyperoxia did not significantly change hepatocyte proliferation and apoptosis.