Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

Sulforhodamine B colorimetric assay for cytotoxicity screening

Vanicha Vichai, Kanyawim Kirtikara · Nature Protocols · 2006 · 3.6K citations

Cytotoxicity Screening, Medicine, Toxicology +3

Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer

Bruce G. Haffty, Qifeng Yang, Thomas Kearney et al. · Journal of Clinical Oncology · 2006 · 1.1K citations · Full text

A Novel Proteolytic Cleavage Involved in Notch Signaling

Christel Brou, Frédérique Logeat, Neetu Gupta et al. · Molecular Cell · 2000 · 1.1K citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +6

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

Jeff S. Mumm, Eric H. Schroeter, Meera Saxena et al. · Molecular Cell · 2000 · 853 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +10

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

Chang-Yuan Ni, M. Paul Murphy, Todd E. Golde et al. · Science · 2001 · 847 citations