Publication | Closed Access
Asymmetric Synthesis of Maraviroc (UK‐427,857)
48
Citations
34
References
2010
Year
BiochemistryNatural SciencesDiversity-oriented SynthesisAsymmetric SynthesisReceptor AntagonistOrganic ChemistryNew Maraviroc AnaloguesStereoselective SynthesisPharmacologyAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisNatural Product Synthesis
Abstract The asymmetric synthesis of Maraviroc (UK‐427,857), a chemochine receptor 5 (CCR‐5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral β‐amino aldehyde key fragment is presented. The reactions were performed on a gram‐scale and allow for the rapid construction of new Maraviroc analogues.
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