Endothelins in health and disease

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text

Life Sciences, Cell Biology, Physiology +9

Bosentan Therapy for Pulmonary Arterial Hypertension

Lewis J. Rubin, David B. Badesch, Robyn J. Barst et al. · New England Journal of Medicine · 2002 · 2.7K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Cloning and expression of a cDNA encoding an endothelin receptor

Hiroshi Arai, Seiji Hori, Ichiro Aramori et al. · Nature · 1990 · 2.6K citations

Life Sciences, Cell Biology, Physiology +7

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

Adel Giaid, Masashi Yanagisawa, David Langleben et al. · New England Journal of Medicine · 1993 · 1.8K citations · Full text

Medicine, Cardiology, Physiology +11

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Gilberto De Nucci, Ranjeny Thomas, Pedro D’Orléans-Juste et al. · Proceedings of the National Academy of Sciences · 1988 · 1.4K citations · Full text

Medicine, Pharmacology, Physiology +12