Publication | Open Access
A Novel Closed-Circular Mitochondrial DNA with Properties of a Replicating Intermediate
272
Citations
9
References
1971
Year
DnaGeneticsDna AnalysisMolecular BiologyMolecular GeneticsMitochondrial BiogenesisCircular DuplexDna ComputingMitochondrial DnaCell DivisionDna ReplicationCircular Light StrandCell BiologyBiomolecular EngineeringChromatinMitochondrial FunctionNatural SciencesReplicating IntermediateCellular BiochemistryMedicineOrganelle DynamicGenome Editing
A fraction of the covalently closed mitochondrial DNA in mouse L cells contains a replicated heavy-strand segment that is hydrogen bonded to the circular light strand. The inserted single strand is dissociable from the circular duplex at an elevated temperature.
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