Histamine: Differences in Amount Available for Release in Lungs of Guinea Pigs Susceptible and Resistant to Acute Anaphylaxis

Abstract

Susceptibility to acute anaphylaxis in guinea pigs is related to the quantity of liberable histamine available for release in the lung. In highly suscepti-ble Hartley animals this amount can be more than 10 times greater than in the resistant strain 2. Strain 2 and Hartley guinea pigs are equally susceptible to his-tamine toxicity, and their organs fix I(131)-labeled antibody equally well.