Biological and Pharmaceutical Bulletin · 2004 · 51 citations · 17 references
Life SciencesNeurobiologyNeuroscienceCell SignalingMolecular NeuroscienceSignal TransductionAstrocyte BiologyGrowth Factor SignalingNerve RegenerationNervous TissueNeuroprotectionNeurotrophic FactorsMitogen-activated Protein Kinase KinaseNerve Growth Factor SignalingNeurite Outgrowth InhibitionProtein Kinase G SignalingProtein Kinase Inhibitors
Liriope platyphylla (LP) has been used as a tonic, antitussive, and expectorant in Korea for many years. In this study, we found that the buthanol fraction of Liriope platyphylla (BLP)-conditioned media of C6 and primary astrocyte induced the neurite outgrowth of PC12 cells, and that the effect was reversed by addition of nerve growth factor (NGF)-antibody and GF109203X, an inhibitor of protein kinase (PKC). Furthermore, we demonstrated that BLP increased the expression and secretion of NGF. GF109203X also decreased NGF expression in C6 cells. Taken together, our results suggest that astroglial NGF enhanced by BLP in a PKC-dependent pathway contributed to the induction of neurite outgrowth of PC12 cells.
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Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
PJ Whitehouse, DL Price, R. G. Struble et al. · Science · 1982 · 3.6K citations