Publication | Closed Access
Antitumor Agents, 110, Bryophyllin B, a Novel Potent Cytotoxic Bufadienolide from Bryophyllum pinnatum
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1989
Year
Bioorganic ChemistryMolecular BiologyMedicinal FungiChemical BiologyPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryAntitumor AgentsDifference Noe MethodPhytopharmacologyAnti-cancer AgentPhytoalexinBryophyllum PinnatumBiochemistryPharmacologyBryotoxin CNatural SciencesBryophyllin BMicrobiologyMedicineDrug Discovery
Bryophyllin B [1], a potent cytotoxic bufadienolide, has been isolated from Bryophyllum pinnatum and its structure confirmed by the use of 2D-nmr techniques and difference nOe method. Transformation of bryotoxin C [2] to 1 with acid is also discussed.