Concepedia

Publication | Closed Access

Diabetes With Mitochondrial Gene tRNALYS Mutation

DOI

35

Citations

0

References

1994

Year

Susumu Suzuki, Yoshinori Hinokio, Satoshi Hirai, Masatoshi Onoda, Masahiro Matsumoto, Masataka Ohtomo, Hiromasa Kawasaki, Yoshinori Sato, Hiroaki Akai, Kohji Abe,
Diabetes Care

Abstract

This observation is the first report of association of diabetes with the mitochondrial tRNA(LYS) mutation. Insulin secretory capacity was significantly lower in the mutant members than in the nonmutated members. These findings suggest that the pancreatic beta-cell secretory defect of insulin might be one of the phenotypes of the mitochondrial tRNA(LYS) mutation.