Concepedia

Formal Inverse Sonogashira Reaction: Direct Alkynylation of Arenes and Heterocycles with Alkynyl Halides

Alexander S. Dudnik, Vladimir Gevorgyan

Angewandte Chemie International Edition · 2010 · 334 citations · 14 references

DOIFull text

Open access

Concepts

Abstract

Getting straight to the point: Recent developments in the direct functionalization of unreactive CH bonds have established the title reaction (see scheme). Various main-group (M) and transition metals (TM) serve as efficient promoters or catalysts for this transformation.

References

14

Direct Alkynylation of Indole and Pyrrole Heterocycles

Jonathan P. Brand, Julie Charpentier, Jérôme Waser · Angewandte Chemie International Edition · 2009 · 432 citations · Full text

, , +11

Direct Palladium-Catalyzed Alkynylation of N-Fused Heterocycles

Victoria Ryabova, Vladimir Gevorgyan · Journal of the American Chemical Society · 2007 · 276 citations · Full text

, , +9

Palladium-Catalyzed Direct Alkynylation of C−H Bonds in Benzenes

Mamoru Tobisu, Yusuke Ano, Naoto Chatani · Organic Letters · 2009 · 241 citations

, , +11

Copper as a Powerful Catalyst in the Direct Alkynylation of Azoles

François Besselièvre, Sandrine Piguel · Angewandte Chemie International Edition · 2009 · 198 citations

, , +15

Nickel-Catalyzed Direct Alkynylation of Azoles with Alkynyl Bromides

Naoto Matsuyama, Koji Hirano, Tetsuya Satoh et al. · Organic Letters · 2009 · 194 citations

, , +9