Organic Letters · 2012 · 253 citations · 35 references
Natural SciencesChemistryCatalysisGreen ChemistryOrganometallic ChemistryHeterocyclic ChemistryRedox ChemistryC - H Bond FunctionalizationScopeTransition-metal-catalyzed Functionalization
A cationic ruthenium(II) complex enabled efficient oxidative alkenylations of anilides in water as a green solvent and proved applicable to double C-H bond functionalizations of (hetero)aromatic amides with ample scope. Detailed studies provided strong support for a change of ruthenation mechanism in the two transformations, with an irreversible metalation as the key step in cross-dehydrogenative alkenylations of benzamides.
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Efficient catalytic addition of aromatic carbon-hydrogen bonds to olefins
Shinji Murai, Fumitoshi Kakiuchi, Shinya Sekine et al. · Nature · 1993 · 1.4K citations