Analysis of polymorphisms of tumor necrosis factor‐α and polymorphic xenobiotic metabolizing enzymes in inflammatory bowel disease: Study from northern India

Abstract

'Null' genotypes of GSTM1 and T1 are associated with IBD and the combination of the two GST genotypes further increases the risk, possibly due to gene-gene interaction. TNF-alpha is unlikely to be an important determinant of susceptibility to IBD in the Indian population.