Isoflurane and Pentobarbital Reduce AMPA Toxicity In Vivo  in the Rat Cerebral Cortex

Abstract

Isoflurane and pentobarbital reduced cortical AMPA excitotoxicity. The magnitude of injury reduction was similar to that produced by NBQX when the anesthetics were administered in EEG-BS doses. These results are consistent with the previously demonstrated ability of isoflurane and pentobarbital to inhibit AMPA receptor responses.