The chemical and biological activities of quinones: overview and implications in analytical detection

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

Hjördis Thor, Martyn T. Smith, Pia Hartzell et al. · Journal of Biological Chemistry · 1982 · 903 citations · Full text

Life Sciences, Biochemistry, Toxicology +16

The enzymes of detoxication.

William B. Jakoby, Daniel M. Ziegler · Journal of Biological Chemistry · 1990 · 413 citations · Full text

Life Sciences, Biochemistry, Enzymology +5

Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis

Gautam Sethi, Kwang Seok Ahn, Bharat B. Aggarwal · Molecular Cancer Research · 2008 · 316 citations

Life Sciences, Medicinal Chemistry, Pharmacology +15

Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues

David Siegel, David Ross · Free Radical Biology and Medicine · 2000 · 295 citations

Life Sciences, Biochemistry, Molecular Biology +10

Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity

Venugopal Radjendirane, Pius Joseph, Ying-Hue Lee et al. · Journal of Biological Chemistry · 1998 · 262 citations · Full text

Life Sciences, Genetics, Molecular Biology +16