Hyperuricosuric encephalopathy without hyperuricaemia.

A familial disorder of uric acid metabolism and central nervous system function

Michael Lesch, William L. Nyhan · The American Journal of Medicine · 1964 · 1.5K citations

Life Sciences, Neurology, Neuroscience +9

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

J. Edwin Seegmiller, Frederick M. Rosenbloom, William N. Kelley · Science · 1967 · 1.2K citations

Life Sciences, Biochemistry, Neurology +14

URIC ACID PRODUCTION IN GOUT

J. Edwin Seegmiller, Arthur I. Grayzel, Leonard Laster et al. · Journal of Clinical Investigation · 1961 · 227 citations · Full text

Life Sciences, Biochemistry, Physiology +7

Genetics of an X-Linked Disorder of Uric Acid Metabolism and Cerebral Function

William L. Nyhan, Joseph J. Pesek, Lawrence Sweetman et al. · Pediatric Research · 1967 · 111 citations

Life Sciences, Genetics, Neuroscience +12

Hereditary Choreoathetosis, Self-Mutilation and Hyperuricemia in Young Males

D. Hoefnagel, E. Andrew, Norman G. Mireault et al. · New England Journal of Medicine · 1965 · 101 citations

Medicine, Genetics, Pediatrics +8