Concepedia

Free-Radical-Initiated Coupling Reaction of Alcohols and Alkynes: Not C−O but C−C Bond Formation

Zhong‐Quan Liu, Liang Sun, Jianguo Wang, Jie Han, Yankai Zhao, Bo Zhou

Organic Letters · 2009 · 130 citations · 18 references

DOIFull text

Open access

Concepts

Abstract

This work demonstrates an efficient method to prepare allylic alcohols via direct C-C bond formation using electron-rich alkynes and aliphatic alcohols initiated by tert-butyl hydroperoxide.

References

18

Catalytic Markovnikov and anti‐Markovnikov Functionalization of Alkenes and Alkynes: Recent Developments and Trends

Matthias Beller, Jayasree Seayad, Annegret Tillack et al. · Angewandte Chemie International Edition · 2004 · 1.1K citations · Full text

, , +14

The Design and Application of Free Radical Chain Reactions in Organic Synthesis. Part 2

Dennis P. Curran · Synthesis · 1988 · 791 citations

, , +8

CuBr-Catalyzed Efficient Alkynylation of sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2004 · 665 citations

, , +12

Cu-catalyzed cross-dehydrogenative coupling: A versatile strategy for C–C bond formations via the oxidative activation of sp <sup>3</sup> C–H bonds

Zhiping Li, D. Scott Bohle, Chao‐Jun Li · Proceedings of the National Academy of Sciences · 2006 · 592 citations · Full text

, , +14

Highly Efficient Copper-Catalyzed Nitro-Mannich Type Reaction:  Cross-Dehydrogenative-Coupling between sp<sup>3</sup> C−H Bond and sp<sup>3</sup> C−H Bond

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2005 · 538 citations

, , +11