Oxidative Amidation of Aldehydes and Alcohols with Primary Amines Catalyzed by KI‐TBHP

Abstract

Abstract Oxidative amidation of aldehydes and alcohols with amines to afford the corresponding amides in excellent yields and ee values over 98 % is achieved by using a catalytic amount of KI in combination with TBHP as the external oxidant. This method avoids the use of expensive and/or air‐sensitive reagents. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)