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Reduction of cephalosporanic acids with chromium(II) salts: synthesis of 3-methylenecepham derivatives
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1972
Year
Chemical EngineeringMedicinal ChemistryDerivativesCephalosporanic Acids3-Methyl-3-cephem DerivativesDerivative (Chemistry)Natural SciencesMedicineNovel OrganocatalystsOrganic ChemistryCephalosporanic Acid DerivativesChemistry3-Methylenecepham DerivativesPharmacologyChemical DerivativeSynthetic ChemistryChromatographyNatural Product Synthesis
Cephalosporanic acid derivatives (I) were converted into 3-methylenecepham derivatives (II) on treatment with chromium(II) salts in aqueous media, and esters of 3-methylenecepham derivatives were readily isomerized to the 3-methyl-3-cephem derivatives (VII) under basic conditions.