A SIMPLE ONE-POT CONVERSION OF ARYL HALIDES INTO ARYLACETONITRILES

Hitomi Suzuki, Tsutomu Kobayashi, Yoshiki Yoshida, Atsuhiro Osuka

Chemistry Letters · 1983 · 28 citations · 5 references

Concepts

Abstract

Abstract When heated in hexamethylphosphoric triamide in the presence of copper(I) iodide, aryl iodides and bromides react with cyanoacetate anion to form arylcyanoacetates, which lose the ester group on hydrolysis, giving the corresponding arylacetonitriles in good to moderate yields.

References

5