Renal Tubular Acidosis and Renal Potassium Wasting Acquired as a Result of Hypercalcemic Nephropathy

Abstract

THE earliest lesions of certain types of experimental nephrocalcinosis involve the distal portions of the renal tubules and the collecting ducts.1 , 2 Disturbances in renal tubular function might therefore be expected to characterize patients with hypercalcemic renal disease. Many such patients are unable to concentrate their urine normally; impairment of other specific tubular functions, however, has not been widely reported.We have recently had the opportunity to study a boy with hypercalcemic nephropathy in whom renal tubular acidosis and renal potassium wasting apparently developed as a result of repeated episodes of vitamin D intoxication. The purpose of this paper is to . . .