AIDS Research and Human Retroviruses · 2007 · 23 citations · 21 references
Life SciencesImmunologyInfectious DiseasesMucosal ImmunologyVaccine ImmunologyVaccinologyCell-mediated ImmunityMucosal Immune SystemMucosal ImmunityMucosal ImmunizationMucosal T CellsMucosal VaccinesCd8 Positive T Cell ResponsesCodon Usage BiasIntestinal Mucosal ImmunityMucosal ImmunogenicityMucosal T Cell Responses To InfectionMucosal T Cell Responses To VaccinationMucosal T-cell ResponsesParenteral Vaccine Formulations
Oral immunization is a safe and easily applicable route to induce mucosal immunity to HIV infection. We examined the ability of oral attenuated Salmonella typhimurium (ST) vaccine expressing Gag for the efficiency of generating Gag-specific mucosal IgA and CD8+ T cell responses in intestinal lymphoid tissues. By optimizing the codon of HIV-1 gag to the preferred codon bias of Salmonella, the expression of Gag in Salmonella was dramatically improved. The oral ST-Gag vaccine by itself was not so powerful and induces little Gag-specific CD8+ T cell responses in the intestine. Nevertheless, we found that it potentiates otherwise weak intestinal CD8+ T cell responses in nasally primed mice with Gag p24 and cholera toxin adjuvant. Thus, the oral delivery of Salmonella expressing Gag would be utilized in combination with other parenteral vaccine to direct and strengthen intestinal HIV-specific CTL responses.
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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
J. Rodrigo Mora, Marı́a Rosa Bono, N. Manjunath et al. · Nature · 2003 · 1.1K citations · Full text
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
Qingsheng Li, Lijie Duan, Jacob D. Estes et al. · Nature · 2005 · 945 citations