Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains - Concepedia

Concepedia

Publication | Open Access

Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains

DOI Full Paper Access

44

Citations

42

References

2013

Year

Marco R. Schroeter, Maren Leifheit‐Nestler, Astrid Hubert, Bettina Schumann, Roland Glückermann, Norman Eschholz, Nenja Krüger, Susanne Lutz, Stavros Konstantinides, Katrin Schäfer

Cardiovascular Research

Abstract

Our findings suggest that apoE mediates the effects of leptin on vascular lesion formation by stabilizing cav-1-enriched cell membrane microdomains in SMCs, thus allowing NADPH oxidase assembly and ROS-mediated mitogenic signalling.

References

	Year	Citations

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