ANALYSES OF SINGLE NUCLEOTIDE POLYMORPHISMS AND HAPLOTYPE LINKAGE OF LOC387715 AND THE HTRA1 GENE IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION IN A CHINESE COHORT

Abstract

Both SNPs are significantly associated with exudative AMD in the Chinese cohort and seem to contribute equally to the disease status. A higher frequency of homozygous risk genotypes and risk haplotype and a lower frequency of protective haplotype in the Chinese may be the cause of higher prevalence of exudative AMD in the Chinese than in the whites.