What determines skin sensitization potency–myths, maybes and realities. Part 1. The 500 molecular weight cut‐off

Abstract

The 500 MW cut-off for skin sensitization is a myth, probably derived from the widespread misconception that ability to efficiently penetrate the stratum corneum is a key determinant of sensitization potency. The scarcity of sensitizers with MW > 500 simply reflects the general scarcity of chemicals with MW > 500.