International Clinical Psychopharmacology · 1994 · 300 citations · 0 references
MedicinePharmacotherapyPsychiatryClinical PharmacologyNeuropharmacologyPsychopharmacologyAntidepressant PharmacologyAntidepressant PharmacotherapyAntidepressant TherapyDepression ManagementDepression PharmacotherapyAntidepressant EfficacyAntidepressant MedicationsAntidepressant ResponseAntidepressant SafetyAntidepressant TolerabilityDouble-blind TrialsMajor DepressionMelancholic Depression
The antidepressant efficacy and short-term safety of venlafaxine and fluoxetine were compared in 68 patients hospitalized with major depression and melancholia. Venlafaxine was superior in efficacy to fluoxetine; total scores for both the MADRS and the HAM-D were significantly (p < or = 0.05) lower in the venlafaxine group than in the fluoxetine group at Weeks 4 and 6. Overall tolerance was similar for the two treatments.