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SOMATOMEDIN GENERATING ACTIVITY OF THE 20,000-DALTON VARIANT OF HUMAN GROWTH HORMONE
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1981
Year
Animal PhysiologyGrowth HormoneBiochemistryHuman GrowthHuman Growth HormoneMedicinePhysiology20,000-Dalton VariantEndocrine MechanismSomatomedin Generating ActivityMetabolismEndocrinologyPharmacologySomatomedin ActivityDrug Discovery
The 20,000-dalton variant of human growth hormone stimulated production of somatomedins in the hypophysectomized rat. Somatomedin activity was measured by a radioreceptor assay. The results indicate that the insulin--like activities of human growth hormone that are greatly diminished in the variant are not prerequisites for somatomedin production.