Uric Acid Nephropathy in Leukemia

Abstract

A NEPHROPATHY manifested by hyperuricemia, azotemia, oliguria and occasionally complete anuria has been described as a complication during therapy of neoplasms of the hematopoietic system.1 2 3 The syndrome is assumed to result from intrarenal or extrarenal urinary obstruction by uric acid crystals. Awareness of this complication is prevalent although reports of its occurrence in children are seldom found in the literature.1 , 4 Prevention of this nephropathy depends upon recognition of the conditions under which it occurs so that adequate measures may be promptly taken to increase the solubility of uric acid in the urine. The administration of large quantities of fluid and . . .