Ferrier Glycosylation Reaction Catalyzed by Bi(OTf)<sub>3</sub>-Montmorillonite K-10: Efficient Synthesis of 3,4-Unsaturated Sialic Acid Derivatives - Concepedia

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Ferrier Glycosylation Reaction Catalyzed by Bi(OTf)<sub>3</sub>-Montmorillonite K-10: Efficient Synthesis of 3,4-Unsaturated Sialic Acid Derivatives

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2008

Year

Kiyoshi Ikeda, Yayoi Ueno, Satoru Kitani, Reiko Nishino, Masayuki Sato

Chemical EngineeringEngineeringSialic AcidOrganic ChemistryOrganometallic CatalysisCatalysisEfficient SynthesisChemistryNatural Product SynthesisFerrier Glycosylation ReactionSynthetic ChemistryMontmorillonite K-10 Clay

Abstract

The reaction of the 4,5-oxazoline derivative of sialic acid with various alcohols was effectively promoted by a catalytic amount of montmorillonite K-10 clay supported Bi(OTf)3 to produce a variety of 3,4-unsaturated sialic acids via the Ferrier glycosylation reaction in moderate yields.