The synthesis of novel heterocyclic substituted α-amino acids; further exploitation of α-amino acid alkynyl ketones

Abstract

A range of novel heterocyclic substituted α-amino acids has been synthesised by cyclocondensations of (S)-2-tert-butoxycarbonylamino-4-oxohex-5-ynoic acid tert-butyl ester with enamines, phenylhydrazine, hydroxylamine and phenyl azide.