Human Monocyte-Derived Neohepatocytes: A Promising Alternative to Primary Human Hepatocytes for Autologous Cell Therapy

Abstract

These data convincingly show that NeoHep cells display a phenotype and specific in vitro metabolic functions that are quantitatively and qualitatively comparable in part with those of primary human hepatocytes. These cells could thus be clinically applied in an autologous setting for the treatment of end-stage liver diseases or for improving liver function in patients who have undergone critical liver-mass resection.