Cytotoxicity of metronidazole (Flagyl) and misonidazole (Ro-07-0582): enhancement by lactate

Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

Jagjit K. Mohindra, Andrew M. Rauth · PubMed · 1976 · 182 citations

Medicine, Pharmacology, Chemotherapy +14

Selective chemotherapy of noncycling cells in an in vitro tumor model.

Robert M. Sutherland · PubMed · 1974 · 170 citations

Medicine, Oncology, Pharmacology +10

Radiosensitization of anoxic cells by metronidazole

Josh Foster, R. L. Willson · British Journal of Radiology · 1973 · 118 citations

Medicine, Pharmacology, Toxicology +16

Hypoxic Cell Radiosensitizers: Comparative Tests of Some Electron Affinic Compounds Using Epidermal Cell Survival in Vivo

J. Denekamp, B. D. Michael, Susan R. Harris · Radiation Research · 1974 · 104 citations

Medicine, Pharmacology, Radiation Oncology +15

Toxicity of Nitro Compounds Toward Hypoxic Mammalian Cells In Vitro: Dependence on Reduction Potential

G.E. Adams, Ian J. Stratford, R. G. WALLACE et al. · JNCI Journal of the National Cancer Institute · 1980 · 103 citations

Medicine, Radiation Oncology, Toxicology +15