Global Ischemia Impairs ATP-Sensitive K⁺Channel Function in Cerebral Arterioles in Piglets

Abstract

Ischemia transiently eliminates cerebral arteriolar dilation to activation of ATP-sensitive K+ channels; arteriolar responses are suppressed at 1 hour and return toward normal over 2 to 4 hours. In addition, reduced responsiveness can be prevented by prior treatment with indomethacin.