Developmental exposure to 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin alters postnatal T cell phenotypes and T cell function and exacerbates autoimmune lupus in 24‐week‐old SNF₁mice

Abstract

Developmental TCDD exposure can permanently alter T lymphopoiesis in autoimmune-prone SNF1 mice. The alteration profile is beyond the classic immune suppression response, to also include exacerbation and induction of a lupuslike autoimmune disease.