Further Observations on the Effects of Abruptly Increased Osmotic Pressure of Plasma on Cerebrospinal-Fluid Pressure in Man

Abstract

I N A previous publication, 7 it was assumed tha t hypertonic solutions introduced into the venous system produced cerebral decompression by the creation of an increment in the blood to the brain. The preliminary data seemed to indicate a direct relationship between the degree of fall in cerebrospinal-fluid pressure and the magnitude of this increment. The present investigation was under taken to substantiate this hypothesis and to explore further the effects of such osmotic agents.