Pubo-Urethral Ligament Injury Causes Long-Term Stress Urinary Incontinence in Female Rats: An Animal Model of the Integral Theory

Abstract

Our results show that pubo-urethral ligament deficiency in the female rat induces long-term stress urinary incontinence that is comparable to that in the established stress urinary incontinence model via pudendal nerve transection. Our novel rat model could be used to investigate mechanisms of stress urinary incontinence in females, including the role of urethral hypermobility and potential therapeutic interventions for stress urinary incontinence.