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Trifluoromethylation of Alkenyl Bromides and Iodides (Including 5-Iodouracils) with (CF<sub>3</sub>)<sub>2</sub>Hgand Cu (“Trifluoromethylcopper”)<sup>1</sup>
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Citations
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References
2007
Year
HalogenationInorganic ChemistryChemical Engineering“ Trifluoromethylcopper ”EngineeringAlkene MetathesisIodoalkenes Undergo TrifluoromethylationFluorous SynthesisOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryAlkenyl BromidesVariable Stereochemical InversionStereochemical RetentionBiomolecular Engineering
Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with "CF3Cu" generated from (CF3)2Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.
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