Iron(III)‐Catalyzed Synthesis of 1,2,4‐Trisubstituted Imidazoles through the Reactions of Amidines and Aldehydes in Air

Abstract

Abstract A novel and efficient iron(III)‐catalyzed synthesis of 1,2,4‐trisubstituted imidazoles through the reactions of amidines and aldehydes in air has been developed. Five hydrogen dissociations involving CH and NH bond activation are realized under mild conditions in this approach. The procedure is sustainable, simple and environmentally friendly. magnified image