Probing Wavelength Regulation with an Engineered Rhodopsin Mimic and a C15‐Retinal Analogue

Abstract

Shield and control: The application of a protein design strategy to interrogate the perception of color is described. Cellular retinoic acid binding protein II (see structure) was used first to show that complete encapsulation of the chromophore is critical to achieve an opsin shift comparable to the one observed for rod rhodopsin, and second to show that a rhodopsin protein mimic capable of binding a retinoid analogue responds to changes in electrostatic environments. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.