Labeling with 131I of chloroquine-analogues for the detection of ocular melanoma

Abstract

Electrophilic iodination of chloroquine with 131I by the chloramine-T method results in labeled 3-iodochloroquine (maximum yield 30%) and a number of other labeled quinolines. This method also gives 3-chlorochloroquine in mass amounts. Higher yields (up to 60%) of labeled 3-iodochloroquine are obtained by isotopic exchange with 131I-iodide as its phosphate-salt.