Silica in Water: A Potentially Valuable Reaction Medium for the Synthesis of Pyrano[2,3-c]pyrazoles

Abstract

In the last decade, multicomponent reactions have been much utilized for the synthesis of diverse highly functionalized molecules 1 via the formation of carbon-carbon and carbon-heteroatom bonds in one pot; as an outcome, they have appeared as a significant tool in organic synthesis. 2 These reactions are straightforward one step transformations involving a pair of reactions in which the product of the first is a substrate for the second. This technique becomes even more attractive and efficient if it works under greener reaction conditions. Green chemistry has created its own position in organic chemistry, since it has been demonstrated that how fundamental scientific methodologies can protect human health and the environment in an economically beneficial manner. 3 Therefore, there has been great quest towards the development of greener chemical processes. A part of this quest involves the search of surrogates for the traditionally employed homogenous catalysts. In this regard, many efforts have been made to prepare