Non‐random karyotypic evolution in chronic myeloid leukemia

TLDR

Chromosome banding was performed on bone‑marrow and spleen cells from 10 blastic‑phase CML patients. Karyotype analysis revealed that additional chromosomal changes beyond the Philadelphia chromosome were non‑random, with extra Ph1, trisomy 8, and trisomy 17q occurring in all examined cases and present in 88 % of 57 literature‑reviewed patients, indicating a major evolutionary route.

Abstract

Abstract The chromosome banding pattern was analyzed in bone‐marrow cells and/or spleen cells of 10 patients in the blastic phase of chronic myeloid leukemia (CML). It was obvious from the karyotype analysis that the chromosome aberrations occurring in addition to the Philadelphia chromosome (Ph 1 ) were strictly non‐random. An extra Ph 1 , trisomy 8 and/or trisomy for the long arm of chromosome 17 were observed in all cases. This consistent pattern of chromosome involvement in CML was confirmed in 57 cases from the literature studied with banding techniques. In 88% of the total number of cases with further changes at least one of the three main chromosomal aberrations was found (“major route” of karyotypic evolution).