The Influence of Changes in pH of the Perfusion Fluid on the Occurrence of the Calcium Paradox in the Isolated Rat Heart

Abstract

During Langendorff perfusion of isolated rat hearts the minimum duration of the calcium-free perfusion period, after which reperfusion with calcium evokes the “calcium paradox”, is influenced by changes in pH of the perfusion fluid. This time interval is prolonged by a decreased pH and shortened by an increased pH.